Payne rearrangement route to the optically active oxirane precursor for the preparation of triazole antifungals

DOI: 10.1248/cpb.40.562

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 562 - 564 (1992)

Update date:2022-07-29

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Authors:

Konosu Konosu

Miyaoka Miyaoka

Tajima Tajima

Oida Oida

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Article abstract of DOI:10.1248/cpb.40.562

Optically active epoxide 1, an important intermediate for the preparation of antifungal triazole-amides 2, was synthesized starting from the (S)-lactic acid-derived ketone 9 and taking advantage of the Payne rearrangement of the epoxyalcohol 8.

Full text of DOI:10.1248/cpb.40.562

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