Aerobic Copper-Promoted Radical-Type Cleavage of Coordinated Cyanide Anion: Nitrogen Transfer to Aldehydes to Form Nitriles

Article abstract of DOI:10.1021/jacs.5b10945

We have disclosed for the first time the copper-promoted C≡N triple bond cleavage of coordinated cyanide anion under a dioxygen atmosphere, which enables a nitrogen transfer to various aldehydes. Mechanistic study of this unprecedented transformation suggests that the single electron-transfer process could be involved in the overall course. This protocol provides a new cleavage pattern for the cyanide ion and would eventually lead to a more useful synthetic pathway to nitriles from aldehydes.

Full text of DOI:10.1021/jacs.5b10945

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Aerobic Copper-Promoted Radical-Type Cleavage of Coordinated
Cyanide Anion: Nitrogen Transfer to Aldehydes to Form Nitriles
Qian Wu, Yi Luo, Aiwen Lei, and Jingsong You
J. Am. Chem. Soc., Just Accepted Manuscript • DOI: 10.1021/jacs.5b10945 • Publication Date (Web): 23 Feb 2016
Downloaded from http://pubs.acs.org on February 24, 2016
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Aerobic Copper-Promoted Radical-Type Cleavage of Coordi-
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