Bioorganic and Medicinal Chemistry Letters p. 3128 - 3135 (2009)
Update date:2022-07-30
Topics:
Zhou, Yuefen
Vu, Khang
Chen, Yongsheng
Pham, John
Brady, Thomas
Liu, Gang
Chen, Jinhua
Nam, Joonwoo
Murali Mohan Reddy
Au, Qingyan
Yoon, Il Sang
Tremblay, Marie-Helene
Yip, Gary
Cher, Charmian
Zhang, Bin
Barber, Jack R.
Ng, Shi Chung
Chloro-oxime derivatives were investigated as novel small molecule chaperone amplifiers. Lead optimization led to the discovery of compounds that displayed potent HSF1 activation activity, significant cytoprotection in MG-132 stress, ER stress and PolyQ stress cell models (EC50 < 10 μM).
View MoreSuzhou Ryan Pharmachem Technology Co.,Ltd
Contact:+86-0512-68780025
Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China
Contact:+86-27-67841589
Address:Add: 999 Gaoxin Road, Donghu New Technology Development Zone, Wuhan City, Hubei, China
AUSHUN PHARMACEUTICAL TECHNOLOGY CO,.LTD
Contact:+86-25-86883560 15951806178
Address:14 Dayingbi, Zhujiang Rd. East, Nanjing, Jiangsu, China.
Contact:+86-20-32051076
Address:1105,Building A, International Business Incubator,Science City
Changzhou Screw International Trading Co., Ltd.
Contact:13906149256,18001495888
Address:Jiangsu，Jintanqu
Doi:10.1002/ejoc.201601435
(2017)Doi:10.1016/j.bmcl.2009.04.085
(2009)Doi:10.1016/j.bmcl.2009.04.094
(2009)Doi:10.1039/c9gc01958h
(2019)Doi:10.1016/j.tetlet.2009.05.056
(2009)Doi:10.1039/b903797g
(2009)
