A convenient synthesis of 4-aminomethyl-L-phenylalanine

Article abstract of DOI:10.1080/00397919108019817

N-Boc-4-aminomethyl-L-phenylalanine is prepared from N-Boc-4-iodophenylalanine in 78% yield over three steps. The method features an efficient Pd-catalyzed carbonylation, oxime formation, and subsequent catalytic reduction employing an ethanol/water/acetic acid solvent system which is crucial to successful reaction.

Full text of DOI:10.1080/00397919108019817

This article was downloaded by: [Duke University Libraries]
On: 03 January 2015, At: 08:07
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
A Convenient Synthesis of 4-
Aminomethyl-L-Phenylalanine
George D. Hartman a & Wasyl Halczenko a
a Merck Sharp & Dohme Research Laboratories ,
West Point, Pa., 19486
Published online: 23 Sep 2006.
To cite this article: George D. Hartman & Wasyl Halczenko (1991) A Convenient
Synthesis of 4-Aminomethyl-L-Phenylalanine, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 21:20,
2103-2107, DOI: 10.1080/00397919108019817
To link to this article: http://dx.doi.org/10.1080/00397919108019817
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the
information (the “Content”) contained in the publications on our platform.
However, Taylor & Francis, our agents, and our licensors make no
representations or warranties whatsoever as to the accuracy, completeness,
or suitability for any purpose of the Content. Any opinions and views
expressed in this publication are the opinions and views of the authors, and
are not the views of or endorsed by Taylor & Francis. The accuracy of the
Content should not be relied upon and should be independently verified with
primary sources of information. Taylor and Francis shall not be liable for any
losses, actions, claims, proceedings, demands, costs, expenses, damages,
and other liabilities whatsoever or howsoever caused arising directly or

indirectly in connection with, in relation to or arising out of the use of the
Content.
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden. Terms & Conditions of access and use can be found at
http://www.tandfonline.com/page/terms-and-conditions