Novel potent dual inhibitors of CK2 and Pim kinases with antiproliferative activity against cancer cells

DOI: 10.1016/j.bmcl.2012.02.099

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3327 - 3331 (2012)

Update date:2022-08-05

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Authors:

Pierre, Fabrice

Regan, Collin F.

Chevrel, Marie-Claire

Siddiqui-Jain, Adam

MacAlino, Diwata

Streiner, Nicole

Drygin, Denis

Haddach, Mustapha

O'Brien, Sean E.

Rice, William G.

Ryckman, David M.

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Article abstract of DOI:10.1016/j.bmcl.2012.02.099

A novel family of potent dual inhibitors of CK2 and the Pim kinases was discovered by modifying the scaffolds of tricyclic Pim inhibitors. Several analogs were active at single digit nanomolar IC₅₀ values against CK2 and the Pim isoforms Pim-1

Full text of DOI:10.1016/j.bmcl.2012.02.099

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