Journal of the Chemical Society. Perkin transactions I p. 871 - 876 (1993)
Update date:2022-08-04
Topics:
Owens, Jonathan
Rees, Lilias
Suckling, Colin J.
Wood, Hamish C. S.
The separation of the (6R)- and (6S)-diastereoisomers of tetrahydrofolic acid by derivatisation on N-5 with chiral auxiliary reagents followed by fractional crystallisation or extraction is described.Chloroformates of chiral alcohols were used as chiral auxiliaries and those derived from cyclic terpene alcohols were found to be most effective for the separation.The cleavage of the derivative and conversion in situ into 5,10-methenyltetrahydrofolic acid which was subsequently hydrolysed to afford 5-formyltetrahydrofolate (leucovorin) was investigated for the derivatised tetrahydrofolates; that from (-)-menthol was the only one that combined satisfactory separation with sufficient lability for efficient conversion into 5-fornyltetrahydrofolate.The characterisation and optical purity of the products is described.
View MoreContact:732.938.2777
Address:5012 Industrial Road Farmingdale, NJ 07727
Taixing Joxin Bio-tec Co.,Ltd.
website:http://www.joxbio.com
Contact:86-523-87558858 87612088
Address:No.88, chengdong industrial park
Contact:0086-357-6662688
Address:Zhaocheng town, Hongtong County, Linfen City, Shanxi Province
Chengdu ZY Biochemical Technology Co., LTD
Contact:0086-28-88680086
Address:170 Qingpu Road, Shouan Town, Pujiang County
Jurong Huaheng Natural Biological Products Factory
website:http://www.risebiochem.com
Contact:+86-13921007726
Address:Chuncheng town,Jurong city,Jiangsu province,China
Doi:10.1016/S0040-4039(00)93510-X
(1991)Doi:10.1016/j.tetlet.2016.05.057
(2016)Doi:10.1002/chem.201103347
(2012)Doi:10.1016/j.tetlet.2012.04.059
(2012)Doi:10.1021/tx200452w
(2012)Doi:10.1002/chem.201103784
(2012)
