Journal of the Chemical Society. Perkin transactions I p. 871 - 876 (1993)
Update date:2022-08-04
Topics:
Owens, Jonathan
Rees, Lilias
Suckling, Colin J.
Wood, Hamish C. S.
The separation of the (6R)- and (6S)-diastereoisomers of tetrahydrofolic acid by derivatisation on N-5 with chiral auxiliary reagents followed by fractional crystallisation or extraction is described.Chloroformates of chiral alcohols were used as chiral auxiliaries and those derived from cyclic terpene alcohols were found to be most effective for the separation.The cleavage of the derivative and conversion in situ into 5,10-methenyltetrahydrofolic acid which was subsequently hydrolysed to afford 5-formyltetrahydrofolate (leucovorin) was investigated for the derivatised tetrahydrofolates; that from (-)-menthol was the only one that combined satisfactory separation with sufficient lability for efficient conversion into 5-fornyltetrahydrofolate.The characterisation and optical purity of the products is described.
View MoreContact:+86-515-88356562
Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
Yancheng Smiling Imp & Exp Co., Ltd.
Contact:+86-515-83173586
Address:Rm1207, BLD#03, Phoenix Plaza, Juheng Road, Yancheng, Jiangsu, P.R. China
SHUNYUANSHENG BIO-PHARMTECH CO., LTD
website:https://www.whsysbio.com
Contact:--
Address:Building 13, Liandong U Valley-Wuhan Economic Innovation Valley, No. 259, Xingsan Road, Shamao Street, Hannan District, Wuhan City, Hubei Province
Anhui Biochem United Pharmaceutical Co., Ltd.
Contact:0086 551 5167062 / 5228268
Address:No. 30 Hongfeng Road, Hi-Tech Development Zone, Hefei (230088), China
Landz International Company Ltd.
Contact:0086-21-58891610
Address:985 Dongfang Road, Pudong, Shanghai 200122 China
Doi:10.1016/S0040-4039(00)93510-X
(1991)Doi:10.1016/j.tetlet.2016.05.057
(2016)Doi:10.1002/chem.201103347
(2012)Doi:10.1016/j.tetlet.2012.04.059
(2012)Doi:10.1021/tx200452w
(2012)Doi:10.1002/chem.201103784
(2012)
