A SIMPLE SYNTHESIS OF ΨGly DIPEPTIDE ISOSTERES VIA REDUCTIVE ELIMINATION OF γ-OXYGENATED α,β-ENOATES WITH ALKENYLCOPPER REAGENTS

Article abstract of DOI:10.1016/S0040-4039(00)93510-X

Readily available protected forms of δ-amino-γ-mesyloxy-α,β-enoates can be converted to protected dipeptide isosters, Ψ<(E)CH=CH>Gly, in high yields by reduction with alkenylcopper reagents. Keywords: dipeptide isosters; Ψ<(E)CH=CH>Gly; γ-mesyloxy-α,β-eno