Unexpected MIMIRC Annulation Between a Lithium Dienolate and Methyl Acrylate

DOI: 10.1016/0040-4039(91)80076-I

Source and publish data:

Tetrahedron Letters p. 5531 - 5534 (1991)

Update date:2022-07-29

Topics:

Authors:

Jaafar, Akram

Alilou, El Houssine

Reglier, Marius

Waegell, Bernard

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Article abstract of DOI:10.1016/0040-4039(91)80076-I

We describe an unusual <2+2+2> MIMIRC reaction between a lithium dienolate 6 and methyl acrylate.The more classical double Michael addition cyclisation provides an efficient entry towards key intermediate 5 for 2-isocyanopupukeanane 1 synthesis.

Full text of DOI:10.1016/0040-4039(91)80076-I

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