Diastereospecific synthesis of D-and L-allo-threonines and trichlorinated derivatives suitable for the preparation of tritium labelled material

Article abstract of DOI:10.1016/S0040-4039(00)74479-0

D- or L- serine can be converted to L- or D-γ,γ,γ-trichloro-allo-treonine, which on catalytic hydrogenolysis give diastereochemistry pure L-allo-threonine respectively. This procedure can be adapted to the preparation of tritium labelled material. D- or L-serine can be converted to L- or D-γ,γ,γ-trichloro-allo-threonine, which on catalytic hydrogenolysis give diastereomerically pure L-allo or D-allo-threonine respectively. This procedure can be adapted to the preparation of tritium labelled material.