Pyrimido[1,6-a]benzimidazoles: A new class of DNA gyrase inhibitors

DOI: 10.1021/jm00086a006

Source and publish data:

Journal of Medicinal Chemistry p. 1385 - 1392 (1992)

Update date:2022-08-02

Topics:

Authors:

Hubschwerlen

Pflieger

Specklin

Gubernator

Gmunder Gmunder

Angehrn Angehrn

Kompis Kompis

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00086a006

Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-a]benzimi

Full text of DOI:10.1021/jm00086a006

Products guided by the article

Product name:2-Benzyloxy-5-ethyl-8-fluoro-7-(4-methyl-piperazin-1-yl)-5H-benzo[4,5]imidazo[1,2-c]pyrimidine-1,3-dione

Cas No:137858-46-9

R&D Labs maybe for 137858-46-9

Henan Techway Chemical Co.,Ltd.

website:http://www.techwaychem.com

Contact:+86-371-66380080

Address:No.27 Shunhe Road,
Shandong Yuanli Science and Technology Co., Ltd.

Contact:86-0536-6777557

Address:Zhuliu Industiral Park,Changle County
Zhejiang Hoshine Silicon Industry Co., Ltd.

Contact:86-573-89179966

Address:Zhapu Town, Pinghu City, Zhejiang, China
Shenyang Xinyihan Chemical Technology Co., Ltd.

Contact:+86-18525026267

Address:362, aigongbeijei street 23 , tiexi district,Shenyang, Liaoning, China
Liao Cheng All Win Chemicals Co.,LTD

Contact:86+0635-2991582

Address:Room 402,Unit 1,No.27 building.Zhong tong shi dai haoyuan,liaocheng city,Shan dong Province.China

Relevant to this article

Naturally occurring bioactive 5-ethylidenehydantoins as inspiration for the development of analogues

Doi:10.1080/00397911.2018.1467457
(2018)
Crystal structures, two-photon absorption and theoretical calculation of a series of bis-vinylpyridine compounds synthesized by one-step solid state reaction

Doi:10.1007/s11426-010-4141-6
(2011)
Aluminum chloride activation of chloro-boronsubphthalocyanine: A rapid and flexible method for axial functionalization with an expanded set of nucleophiles

Doi:10.1021/ic2016935
(2012)
Donor-acceptor dyes incorporating a stable dibenzosilole π-conjugated spacer for dye-sensitized solar cells

Doi:10.1039/c2jm30978e
(2012)
Restricted conformational flexibility of a triphenylamine derivative on the formation of host-guest complexes with various macrocyclic hosts

Doi:10.1002/chem.201103079
(2012)
Biscyclohexane-annulated diethyl dipyrrindicarboxylates: Observation of a dipyrrin form with absent visible absorption

Doi:10.1002/ejoc.201101729
(2012)

Article Doi