Synthesis and angiotensin II receptor antagonist activity of C-linked pyrazole derivatives

DOI: 10.1248/cpb.42.1617

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1617 - 1630 (1994)

Update date:2022-08-04

Topics: Synthesis Mass spectrometry Derivatives ANGIOTENSIN II NMR (nuclear magnetic resonance) pyrazole FT-IR (Fourier Transform Infrared Spectroscopy) HPLC (High Performance Liquid Chromatography) C-linked Receptor antagonist

Authors:

Nicolai Nicolai

Cure Cure

Goyard Goyard

Kirchner

Teulon Teulon

Versigny

Cazes Cazes

Virone-Oddos

Caussade

Cloarec Cloarec

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Article abstract of DOI:10.1248/cpb.42.1617

The synthesis and pharmacological activity of new nonpeptide angiotensin II (AII) receptor antagonists are presented. These 5-O-substituted and 5-C-substituted 3-alkylpyrazole derivatives represent a new series of antagonists and have led to the discovery

Full text of DOI:10.1248/cpb.42.1617

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