A new application of the mild thiolation concept for an efficient three-step synthesis of 2-cyanobenzothiazoles: A new approach to Firefly-luciferin precursors

DOI: 10.1080/17415993.2011.641558

Source and publish data:

Journal of Sulfur Chemistry p. 9 - 16 (2012)

Update date:2022-08-05

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Authors:

Wuerfel, Hendryk

Weiss, Dieter

Beckert, Rainer

Guether, Angelika

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Article abstract of DOI:10.1080/17415993.2011.641558

An easy, low cost and upscalable three-step synthesis of Firefly luciferin precursors is presented. The 6-alkoxy-2-cyano-benzothiazoles (1) were synthesized starting from easily available O-alkylated 4-aminophenoles (2) via a mild thiolation, Jacobsen cyclization and dehydratization sequence.

Full text of DOI:10.1080/17415993.2011.641558

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