Synthesis of (+)-Obafluorin, a β-Lactone Antibiotic

Article abstract of DOI:10.1021/jo00027a006

Optically pure obafluorin (1), an antibacterial agent from Pseudomonas fluorescens, was synthesized via lactonization of N-<(2-nitrophenyl)sulfenyl>-(2S,3R)-2-amino-3-hydroxy-4-(4-nitrophenyl)butanoic acid (6), which was prepared in a stereospecific manne