Journal of Medicinal Chemistry p. 5541 - 5552 (2013)
Update date:2022-08-04
Topics: Activity Experimental Antibiotics
Brown, Matthew F.
Mitton-Fry, Mark J.
Arcari, Joel T.
Barham, Rose
Casavant, Jeffrey
Gerstenberger, Brian S.
Han, Seungil
Hardink, Joel R.
Harris, Thomas M.
Hoang, Thuy
Huband, Michael D.
Lall, Manjinder S.
Lemmon, M. Megan
Li, Chao
Lin, Jian
McCurdy, Sandra P.
McElroy, Eric
McPherson, Craig
Marr, Eric S.
Mueller, John P.
Mullins, Lisa
Nikitenko, Antonia A.
Noe, Mark C.
Penzien, Joseph
Plummer, Mark S.
Schuff, Brandon P.
Shanmugasundaram, Veerabahu
Starr, Jeremy T.
Sun, Jianmin
Tomaras, Andrew
Young, Jennifer A.
Zaniewski, Richard P.
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Rat pharmacokinetic studies with compound 17 demonstrate low clearance and low plasma protein binding. In addition, evidence is provided for a number of analogues suggesting that the siderophore receptors PiuA and PirA play a role in drug uptake in P. aeruginosa strain PAO1.
View MoreHANGZHOU FOREWIN PHARMA CO., LTD
Contact:+86-571-89053961
Address:hangzhou
SHOUGUANG BOYU CHEMICAL CO.,LTD
Contact:+86-536-8256719
Address:ROOM 1101&1103,BUILDING D,ZHONGTU MANSION,NO.6565 EAST FUSHOU STREET,WEIFANG CITY,SHANDONG,CHINA.
Contact:
Address:
Pengchen New Material Technology Co., Ltd.
Contact:+86-512-63680537
Address:99.6 km of national road 318, Meiyan Community,Pingwang Town, Wujiang District, Suzhou 215225
Contact:+86-10-62651721
Address:29 Yongxing Road, Daxing District,Beijing China
Doi:10.1016/j.bmcl.2012.04.025
(2012)Doi:10.1080/15421406.2011.600222
(2011)Doi:10.1016/j.dyepig.2012.03.015
(2012)Doi:10.1016/j.carbpol.2012.12.053
(2013)Doi:10.1021/ol301026w
(2012)Doi:10.1246/cl.1991.1973
(1991)