A nitro sugar-mediated stereocontrolled synthesis of β2- amino acids: Synthesis of a polyhydroxylated trans-2-aminocyclohexanecarboxylic acid

Article abstract of DOI:10.1002/ejoc.201200103

The first stereocontrolled nitro sugar-mediated synthesis of polyhydroxylated β-amino acids and their incorporation into peptides is described. The key steps of this approach are a Michael addition of the lithium salt of tris(phenylthio)methane (a carboxy