Braces for the peptide backbone: Insights into structure-activity relationships of protease inhibitor mimics with locked amide conformations

DOI: 10.1002/anie.201108983

Source and publish data:

Angewandte Chemie - International Edition p. 3708 - 3712 (2012)

Update date:2022-08-04

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Authors:

Tischler, Marco

Nasu, Daichi

Empting, Martin

Schmelz, Stefan

Heinz, Dirk W.

Rottmann, Philipp

Kolmar, Harald

Buntkowsky, Gerd

Tietze, Daniel

Avrutina, Olga

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Article abstract of DOI:10.1002/anie.201108983

Flower power: Potent protease inhibitors containing triazolyl mimics of cis and trans backbone amides were engineered based on the structure of the sunflower trypsin inhibitor 1. The biologically relevant cis-Pro motif was successfully replaced with a non

Full text of DOI:10.1002/anie.201108983

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