Tetrahedron Asymmetry p. 1085 - 1104 (1993)
Update date:2022-08-04
Topics:
Beard, Timothy
Cohen, Mark A.
Parratt, Julian S.
Turner, Nicholas J.
Crosby, John
Moilliet, Jock
An immobilised whole cell Rhodococcus sp. (SP 361) has been shown to be an effective catalyst for the stereoselective hydrolysis of both racemic and prochiral nitrile containing compounds. 2-Alkyl-arylacetonitriles 6a-8a were hydrolysed to (S)-acids and (R)-amides whereas the closely related substrate 9a gave the (R)-acid.A series of prochiral dinitriles 10a-13a were hydrolysed to the corresponding (S)-acids with e.e.'s 22-84percent.Models to account for the stereoselectivity of the enzymic hydrolyses have been proposed.
View MoreZhushan County Tianxin Pharmaceutical & Chemical Co., Ltd.
Contact:0086-719-4224892
Address:Tutang Road, Chengguan Town, Zhushan County, Hubei Province
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Contact:+86-0512-62857507
Address:Boji Science Park, No1688C,Taishan road, Suzhou ,China
Nanjing Chemzam Pharmtech Co., Ltd.
Contact:+86-25-86462165,+86-13915979898
Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China
Zibo Xiaoguang Chemical Material Co., Ltd
Contact:15954099116
Address:Boshan Development Zone
Doi:10.1021/ja00994a056
(1967)Doi:10.1016/S0022-328X(96)06684-3
(1997)Doi:10.1021/ja963066w
(1997)Doi:10.1016/S0040-4039(01)89735-5
(1967)Doi:10.1021/jm960556q
(1997)Doi:10.1016/S0040-4039(96)02308-8
(1997)
