α-Keto amide inhibitors of aminopeptidases

DOI: 10.1021/jm00081a005

Source and publish data:

Journal of Medicinal Chemistry p. 451 - 456 (1992)

Update date:2022-08-03

Topics:

Authors:

Ocain Ocain

Rich Rich

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Article abstract of DOI:10.1021/jm00081a005

The design and synthesis of 3-amino-2-oxo-4-phenylbutanoic acid amides (α-keto amides), a new class of aminopeptidase inhibitor, are described. These compounds, illustrated by the Phe-Leu analogue 2, are effective inhibitors of arginyl aminopeptidase (K(i

Full text of DOI:10.1021/jm00081a005

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