Asymmetric oxidation of β-ketoesters with benzoyl peroxide; enantioselective formation of protected tertiary alcohols

Article abstract of DOI:10.1016/S0040-4039(00)79421-4

Asymmetric oxidation of β-ketoesters by the benzoyl peroxide quench of their lithioenamines formed with (S)-valine t-butyl esters has been accomplished with good enantioselectivity for the formation of tertiary benzoate esters. This procedure thus enables generation of tertiary alcohols in protected form.