Stereoselective synthesis of 3-fluoro azetidinones via the condensation of 2-fluoropropanethioate lithium enolate with imines

Article abstract of DOI:10.1016/0040-4020(95)00869-A

S-Phenyl-2-fluoropropanethioate (1) was treated with lithium diisopropylamide in THF at -78°C to give rise to the lithium enolate, which underwent stereoselective condensation with a variety of aldehyde imines (2) at room temperature to afford the corresp