Useful Syntheses of (3S)-2,3,4,5-Tetrahydropyridazine-3-carboxylic Acid and Its Dehydrotetrapeptide Derivatives

DOI: 10.1246/cl.1991.1953

Source and publish data:

Chemistry Letters p. 1953 - 1956 (1991)

Update date:2022-08-04

Topics: Derivatives Syntheses Experimental

Authors:

Nakamura, Yutaka

Shin, Chung-gi

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Article abstract of DOI:10.1246/cl.1991.1953

The stereoselective synthesis of (3S)-2,3,4,5-tetrahydropyridazine-3-carboxylic acid (Pya), which is a cyclic α-amino acid at center of antrimycins (1), was successful.Moreover, the synthesis of the C-terminal dehydrotetrapeptide of 1 containing Pya residue at N-terminus is described.

Full text of DOI:10.1246/cl.1991.1953

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