Studies on analgesic oligopeptides. VII. Solid phase synthesis and biological properties of Tyr-D-Arg-Phe-βAla-NH2 and its fluorinated aromatic amino acid derivatives

DOI: 10.1248/cpb.39.2316

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2316 - 2318 (1991)

Update date:2022-08-02

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Authors:

Sasaki Sasaki

Ambo Ambo

Suzuki Suzuki

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Article abstract of DOI:10.1248/cpb.39.2316

Tyr-D-Arg-Phe-βAla-NH₂ (I) and its six fluorinated analogs were synthesized. Their opioid receptor binding properties were examined in vitro and their analgesic activity in vivo using the mouse writhing test. It was found that I was one of the

Full text of DOI:10.1248/cpb.39.2316

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