Synthesis of δ-L-α-aminoadipoyl-L-cysteinyl- D-allylglycine, and eight deuterated analogues, substrates for the investigation of the mechanism of action of isopenicillin n synthase

Article abstract of DOI:10.1016/S0040-4020(01)91015-4

The synthesis of δ-L-α-aminoadipoyl-L-cysteinyl-D-allylglycine (1a) from its component amino acids is described, along with the synthesis of eight analogues (1b-i) specifically deuterated at C-3 and/or C-5 of the allyglycine residue.