Imidazo[1,5-a]pyridine-1-ylalkylalcohols: Synthesis via intramolecular cyclization of N-thioacyl 1,2-aminoalcohols and their silyl ethers and molecular structures

Article abstract of DOI:10.1039/c2ob25438g

Iodine-mediated cyclization of N-thioacyl 1,2-aminoalcohols derived from aromatic aldehydes and ketones mainly produced bis(1-imidazo[1,5-a]pyridyl) arylmethanes, whereas the reaction of N-thioacyl 1,2-aminoalcohols derived from aliphatic aldehydes and N-thioacyl 1,2-aminoalcohols protected with a silyl group with iodine gave imidazo[1,5-a]pyridine-1-ylalkylalcohols as a major product.