Chemical and Pharmaceutical Bulletin p. 272 - 278 (1997)
Update date:2022-08-04
Topics:
Akita, Hiroyuki
Umezawa, Isao
Matsukura, Hiroko
Enantioselective hydrolysis of water-insoluble α-acyloxy esters, (±)- 5 and (±)-6, was carried out using lipases immobilized with Celite or a synthetic prepolymer (ENTP-4000 or ENT-4000) in a water-saturated organic solvent to produce chiral intermediates, (2S,3S)-5 and (2S,3R)-4, for the synthesis of diltiazem hydrochloride 1 and (-)-indolmycin 2, respectively. Furthermore, enantioselective hydrolysis of (±)-6 using lipid-lipase aggregates in water-saturated organic solvent was also found to give (2S,3R)- 4.
View MoreShanghai Hohance Chemical Co., ltd
Contact:13914753421
Address:Fl.5；Bld. 70, Lane 1500; Xinfei Road
Beijing Merson Pharmaceutical Co., Ltd
Contact:0086-10-80484934 0086-10-80484574/
Address:2nd Floor , No. 2 Building , No. 14 Houshayu Duan, Jingmi Road ,Shunyi District , Beijing 101318, P.R.China
website:http://www.eastarchem.com/
Contact:1-800-898-2436
Address:1215 K Street, STE 1700
Zhejiang Chemicals Import & Export Corporation (ZHECHEM)
Contact:+86-571-87046953
Address:No. 37, Qingchun Road
LinHai Cina Chemical Co., LTD.
Contact:0576-85580989
Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Doi:10.1016/j.tetlet.2012.05.062
(2012)Doi:10.1055/s-1991-26594
(1991)Doi:10.1016/j.ejmech.2017.11.074
(2018)Doi:10.1039/c3ra46206d
(2014)Doi:10.1139/v72-468
(1972)Doi:10.1016/0040-4020(76)80110-X
(1976)
