Synthesis of teleocidins A, B and their congeners. Part 1. An efficient synthesis method of N-(7-alkyl-4-indolyl)-N-methyl-L-valine esters, essential intermediates for teleocidin synthesis

Article abstract of DOI:10.1016/S0040-4020(01)82397-8

Details of the synthesis method of N-[7-(3,7-dimethyl-1,6-octadien-3-yl)-4-indolyl]-N-methyl-L-valine esters 19 and 20, essential precursors for the tumor promotes lyngbyatoxin A (= teleocidin A-1) (2) and teleocidin A-2 (3) are presented. Key reaction st