New 5-HT3 (serotonin-3) receptor antagonists, I. Synthesis and structure-activity relationships of pyrido[1,2-a]indoles

DOI: 10.1248/cpb.42.2546

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2546 - 2555 (1994)

Update date:2022-08-05

Topics:

Authors:

Kato Kato

Ito Ito

Nishino Nishino

Yamakuni

Takasugi

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Article abstract of DOI:10.1248/cpb.42.2546

A series of pyrido[1,2-a]indol-6(7H)-ones was prepared and evaluated for 5-HT₃ receptor antagonist activity. The structural requirements for the 5-HT₃ receptor antagonist have been defined as an aromatic moiety, a basic nitrogen, and

Full text of DOI:10.1248/cpb.42.2546

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Product name:10-ethyl-8,9-dihydro-7-[(hydroxy)(5-methyl-1-trityl-1H-imidazol-4-yl)methyl]pyrido[1,2-a]indol-6(7H)-one

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