Enantiocontrolled synthesis of the antifungal β-lactam (2R,5S)-2-(hydroxymethyl)clavam

DOI: 10.1248/cpb.39.2212

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2212 - 2215 (1991)

Update date:2022-07-29

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Authors:

Konosu Konosu

Oida Oida

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Article abstract of DOI:10.1248/cpb.39.2212

The antifungal β-lactam (2R,5S)-2-(hydroxymethyl)clavam was synthesized in a convergent and stereocontrolled manner from methyl 6-phthalimidopenicillanate and 2,3-O-isopropylidene-(R)-glyceraldehyde. Convenient methods of acetonide cleavage and phthalimide deblocking are also described.

Full text of DOI:10.1248/cpb.39.2212

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