Nucleophilic Additions to and Reductions of 5-Formyl- and 5-Acyl-2-isoxazolines (4,5-Dihydroisoxazoles): A Stereoselective Route to β,γ-Dihydroxy Ketones

DOI: 10.1039/P19910002613

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 2613 - 2625 (1991)

Update date:2022-07-29

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Authors:

Curran, Dennis P.

Zhang, Jiancun

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Article abstract of DOI:10.1039/P19910002613

Reductions of readily available 5-acyl-2-isoxazolines with L-Selectride follow the Felkin-Anh model and produce syn-5-hydroxyalkyl-2-isoxazolines with excellent (>95:5) selectivities.Swern oxidation of 5-hydroxymethyl-2-isoxazolines, followed by direct ad

Full text of DOI:10.1039/P19910002613

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