Tetrahedron Letters p. 6507 - 6508 (1991)
Update date:2022-07-29
Topics:
Rosenberg, Saul H.
Boyd, Steven A.
Mantei, Robert A.
A Lewis-acid catalyzed anti-aldol reaction of aldehyde 4 afforded diol 6a (95percent de).Aminolysis of the corresponding β-lactone provided erythro-dihydroxyethylene dipeptide isostere 2 while the lactone-protected hydroxyethylene dipeptide isostere 3 was obtained through selective deoxygenation and acidic deprotection. Key words: hydroxyethylene isostere; anti-aldol; aspartic proteinase; renin inhibitor; facial selective
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Doi:10.1021/ja305123v
(2012)Doi:10.1002/chem.201601338
(2016)Doi:10.1021/ol301218x
(2012)Doi:10.1002/cjoc.201201041
(2012)Doi:10.1002/poc.1403
(2008)Doi:10.1016/0223-5234(91)90005-8
(1991)
