Synthesis and in vitro antibacterial activity of 2β and 2α-(substituted methyl) phenoxymethylpenicillins and an oxidation product

Article abstract of DOI:10.1016/0223-5234(91)90005-8

The effect of tereochemical changes on the antibacterial activity of a series of 2-substituted methyl-6β-phenoxyacetamido penams synthesized in our laboratory was studied.The 2α-heteroarylthiomethyl penams were found to be more active than the 2β-substitu