Asymmetric double Michael reaction catalyzed by simple primary amine catalysts: A straightforward approach to construct spirocyclic oxindoles

Article abstract of DOI:10.1002/cjoc.201100543

The enantioselective double Michael reaction of N-Boc-3-nonsubstitued oxindoles with dienones catalyzed by chiral monoimide protected cyclohexane-1,2-diamines was developed. A wide range of optically active spirocyclic oxindoles were obtained up to 98% yield and up to 89% ee.