An Improved Synthesis of 1α-hydroxy Vitamin D3

DOI: 10.1016/S0040-4020(01)80888-7

Source and publish data:

Tetrahedron p. 9419 - 9430 (1991)

Update date:2022-08-03

Topics:

Authors:

Nerinckx, W.

Clercq, P. J. De

Couwenhoven, C.

Overbeek, W. R. M.

Halkes, S. J.

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Article abstract of DOI:10.1016/S0040-4020(01)80888-7

The efficient and stereoselective introduction of the 1α-OH function in vitamin D₃ is described starting from the known previtamin D₃ adduct 6.The sequence involves the stereoselective allylic bromination to 9, followed by substituti

Full text of DOI:10.1016/S0040-4020(01)80888-7

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