5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a New Class of Monoamine Oxidase-B Inactivators

DOI: 10.1021/jm00083a012

Source and publish data:

Journal of Medicinal Chemistry p. 885 - 889 (1992)

Update date:2022-08-03

Topics:

Authors:

Ding, Zhaozhong

Silverman, Richard B.

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Article abstract of DOI:10.1021/jm00083a012

Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids.Both compounds were found to be irreversible inactivators of monoamine oxidase B.These

Full text of DOI:10.1021/jm00083a012

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