5-(Aminomethyl)-3-aryldihydrofuran-2(3H)-ones, a New Class of Monoamine Oxidase-B Inactivators

DOI: 10.1021/jm00083a012

Source and publish data:

Journal of Medicinal Chemistry p. 885 - 889 (1992)

Update date:2022-08-03

Topics:

Authors:

Ding, Zhaozhong

Silverman, Richard B.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00083a012

Both cis- and trans-5-(aminomethyl)-3-aryldihydrofuran-2(3H)-one hydrochloride salts (9 and 10) were synthesized efficiently in a 5-step sequence from arylacetic acids.Both compounds were found to be irreversible inactivators of monoamine oxidase B.These

Full text of DOI:10.1021/jm00083a012

Products guided by the article

Product name:trans-5-(iodomethyl)-3-(4-methoxyphenyl)dihydrofuran-2(3H)-one

Cas No:138878-57-6

R&D Labs maybe for 138878-57-6

Shanghai Forever Synthesis Co.,Ltd.

Contact:021-61124658

Address:Zhoukang Road,Pudong New District,Shanghai,China
Hubei Xinghuo Chemical Co., Ltd.,

Contact:13925817279 13907299441

Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China
EGBERT CORPORATION

Contact:+86 18616952870

Address:Area
Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd

Contact:+86 411 84674606

Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
Arshine Pharmaceutical Co., Limited

website:http://www.cnarshine.com

Contact:0731-88503671

Address:Room 1109.Block C3, Lugu Enterprise Plaza,No.27 Wenxuan Road,Changsha National Hi-Tech Industrial Development Zone,Hunan ,P.R.China

Relevant to this article

A highly convergent asymmetric synthesis of the C(19)-C(27) segment of rifamycin S: An application of enantiodifferentiating acetalization with menthone

Doi:10.1021/jo00032a004
(1992)
A tripeptide-like prolinamide-thiourea as an aldol reaction catalyst

Doi:10.1039/c2ob25693b
(2012)
Synthesis of 3-substituted carboxylate/carboxamide flavone derivatives from 4-hydroxycoumarin, β-nitrostyrene and alcohol/amine using multicomponent reaction

Doi:10.1016/j.tetlet.2016.03.026
(2016)
Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: From hit to clinic

Doi:10.1021/jm5012885
(2014)
SYNTHESIS OF THE N,S-ACETALS OF DIACYL- AND ALKOXYCARBONYL(ACYL)KETENES WITH β-DICARBONYL COMPOUNDS, ORGANIC THIOCYANATES, AND NICKEL(2+) COMPLEXES

Doi:10.1007/BF00961051
(1991)
Exploring the versatility of cycloplatinated thiosemicarbazones as antitumor and antiparasitic agents

Doi:10.1021/om300334z
(2012)

Article Doi