Tjipanazoles, New Antifungal Agents from the Blue-Green Alga Tolypothrix tjipanasensis

Article abstract of DOI:10.1016/S0040-4020(01)81932-3

Bioactivity-directed isolation of the extract of the cyanophyte Tolypothrix tjipanasensis has led to the isolation of fifteen new N-glycosides of indolo<2,3-a>carbazoles designated tjipanazoles A1, A2, B, C1, C2, C3, C4, D, E, F1, F2, G1, G2, I and J.The structures of the alkaloids were determined by physical methods, chemical degradation and synthesis.Tjipanazole J is the only compound having the pyrrolo<3,4-c> ring of previously described indolo<2,3-a>carbazoles.