Microbial transformation of diterpenes: Hydroxylation of sclareol, manool and derivatives by Mucor plumbeus

Article abstract of DOI:10.1016/S0040-4020(01)96175-7

Microbial transformation of several labd-14-ene derivatives has been carried out with a Mucor plumbeus strain. Sclareol (1) (labd-14-en-8α,13β-diol) affords quantitatively a mixture of triols from which the labd-14-en-3β,8α,13β-triol (2) is obtained in high yield. Incubation of other labdane derivatives, including manool (6) [labd-8(17),14-dien-13β-ol], the corresponding 7α-hydroxy derivative (10), manoyl oxide (14) or sclareolide (15) with the same microorganism results in a mixture of various new hydroxylated and keto-derivatives.