Stereospecific synthesis of the enantiomers of nicotinylalanine, a neuroprotecting agent

Article abstract of DOI:10.1016/S0040-4039(00)79583-9

Stereospecific synthesis of the title compounds has been achieved in>95% ee by use of palladium-catalyzed cross-coupling of S- and R-(3-benzyloxycarbonyl-5-oxo-4-oxazolidinyl)-acetyl chloride, respectively, with 3-trimethylstannyl pyridine at room tempera