Improved protective groups for phosphate of o-phosphoserine useful for the solid-phase peptide synthesis

Article abstract of DOI:10.1016/0040-4039(91)85046-8

2-Methylphenyl and 2,6-dimethylphenyl groups on phosphate moiety of O-phosphoserine were more stable in HF treatment than phenyl group and could be effectively removed by hydrogenolysis. They were shown to be protective groups for phosphoserine practicall