Reactions of 5-alkoxyoxazoles with aldehydes in the presence of Lewis acid: Regio- and stereoselective formation of 4-alkoxycarbonyl-2-oxazolines

Article abstract of DOI:10.1016/0040-4039(91)80442-9

The [3 + 2] cycloaddition of 5-alkoxyoxazoles with aldehydes in the presence of the organoaluminum reagent, which was prepared from (±)-2,2′-dihydroxy-1,1′-dinaphthyl and AlMe₃, gave cis-4-alkoxycarbonyl-2-oxazolines in high regio- and stereoselective manner.