An artificial allosteric system: Regulation of a biomimetic reduction (nadh model) by potassium ions

Article abstract of DOI:10.1016/0040-4039(92)88054-9

An acyclic glycol ether ligand with both a quinone and a dimethoxybenzene as terminal groups, reacts with the NADH model 1-propyl-1,4 dihydronicotinamide. The reduction of the quinone exhibits a 30 fold kinetic enhancement in the presence of potassium ions. An effective charge transfer interaction in the transition state of the reduction is probably responsable of this activation effect. The results are discussed in terms of a potassium induced conformational change that mimics allosteric effects.