Synthesis and biological evaluation of benzamides and benzamidines: Structural requirement of a pyrimidine ring for inhibition of EGFR tyrosine kinase

DOI: 10.1016/j.bmcl.2004.02.001

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2299 - 2302 (2004)

Update date:2022-09-26

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Authors:

Asano, Toru

Yoshikawa, Tomohiro

Nakamura, Hiroyuki

Uehara, Yoshimasa

Yamamoto, Yoshinori

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Article abstract of DOI:10.1016/j.bmcl.2004.02.001

The benzamides 1 and the benzamidines 2-3 were synthesized as the mimics of 4-anilinoquinazolines, which possess inhibition of epidermal growth factor receptor (EGFR) tyrosine kinase, and tested for cytotoxicity toward A431 and inhibitory activity toward

Full text of DOI:10.1016/j.bmcl.2004.02.001

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