Glycosylation with sialic acid at HO-3 of three different O-protected D-galactosides in acetonitrile/dichloromethane at low temperature

Article abstract of DOI:10.1016/0040-4039(91)80133-Q

Three different O-protected D-galactosides have been compared as acceptors in α-sialoside synthesis using glycosyl donor 1, methylsulfenyl triflate as promoter, and acetonitrile/dichloromethane as solvent at -70°C. The 6-O-benzylated acceptor 2 was the most efficient, the α(2-3)sialoside 5 was obtained in 39% isolated yield.