Journal of Medicinal Chemistry p. 4264 - 4275 (1993)
Update date:2022-09-26
Topics:
Avery, Mitchell A.
Gao, Fenglan
Chong, Wesley K. M.
Mehrotra, Sanjiv
Milhous, Wilbur K.
A series of C-9 β-substituted artemisinin analogs (2-21) were synthesized via dianion alkylation of the total synthetic intermediate 57 followed by subsequent ozonolysis/acidification, or by alkylation of the enolate derived from (+)-9-desmethylartemisini
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