
Journal of Organic Chemistry p. 2521 - 2523 (1992)
Update date:2022-07-30
Topics:
Murahashi, Shun-Ichi
Sasao, Shigehiro
Saito, Eiichiro
Naota, Takeshi
Hydration of nitriles and transformation of δ-keto nitriles to ene-lactams can be performed efficiently by using RuH2(PPh3)4 catalyst under mild conditions.The effectiveness of the reaction is illustrated by the short-step synthesis of (-)-pumiliotoxin C.
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