Novel 4,4-bis(trifluoromethyl) imidazolines as stereospecific and orally active acyl CoA: Cholesterol acyltransferase (ACAT) inhibitors and antihypercholesterolemic agents

DOI: 10.1016/0960-894X(96)00137-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 885 - 888 (1996)

Update date:2022-07-30

Topics:

Authors:

Boswell, George A.

Li, Hui-Yin

Delucca, Indawari

Billheimer, Jeffrey T.

Drummond, Spencer

Gillies, Peter J.

Robinson, Candy

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0960-894X(96)00137-0

A new class of very potent, systemically-active ACAT inhibitors based on a 4,4-bis(trifluoromethyl)imidazoline ring has been discovered. Compound 6 and its R-enantiomer 6a exhibited very potent oral activities in lowering the serum cholesterol in the animals.

Full text of DOI:10.1016/0960-894X(96)00137-0

Products guided by the article

Product name:Benzamide, 4-fluoro-N-[2-(4-fluorophenyl)-4,5-dihydro-1-methyl-4,4-bis(trifluorometh yl)-1H-imidazol-5-yl]-

Cas No:139981-80-9

R&D Labs maybe for 139981-80-9

Hongyi Import & Export CO.,LTD

Contact:86-13319649499

Address:Nanzheng Neighborhood Commitees, Chongwen Office, Yongding District
Jiangsu Institute of Ecomones Co., Ltd

website:http://www.jsmone.com

Contact:+86-519-82821700

Address:95 Huanyuan N. Road, Jintan, Jiangsu, China
Melone Pharmaceutical Co., ltd

Contact:+86-411 82593920, 82593631

Address:No 232, JInma Roda, Development Zone, Dalian, China
Changsha Huajing Powdery Material Technological Co., Ltd.

Contact:86-731-88879686

Address:Building 2, West Garden, Main Campus of Central South University, Changsha, Hunan Province, China
Hangzhou Maytime Bio-Tech Co.,Ltd.

website:http://www.maytime.com.cn

Contact:+86-571-88925295 88920965

Address:NO.2-1701 Ganghui Central Ningwei Street, Xiaoshan Hangzhou Zhejiang China

Relevant to this article

Novel iron doped calcium oxalates as promising heterogeneous catalysts for one-pot multi-component synthesis of pyranopyrazoles

Doi:10.1039/c6ra25372e
(2017)
Powerful amino diol catalyst for effecting the direct asymmetric conjugate addition of aldehydes to acrylates

Doi:10.1021/ja307668b
(2012)
Scope of the two-step, one-pot palladium-catalyzed borylation/Suzuki cross-coupling reaction utilizing bis-boronic acid

Doi:10.1021/jo301642v
(2012)
Synthesis of fluorescent carboxylic acid ligands for construction of monolayers on nanostructures

Doi:10.2478/s11532-012-0078-2
(2012)
Synthesis and antimicrobial activities of His(2-aryl)-Arg and Trp-His(2-aryl) classes of dipeptidomimetics

Doi:10.1039/c4md00041b
(2014)
Chiral self-assembly of designed amphiphiles: Optimization for nanotube formation

Doi:10.1021/la3030606
(2012)

Article Doi