Central cholinergic agents. II. Synthesis and acetylcholinesterase inhibitory activities of N-[ω-[N-alkyl-N-(phenylmethyl)amino]alkyl]-3-arylpropenamides

DOI: 10.1248/cpb.39.3236

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3236 - 3243 (1991)

Update date:2022-08-04

Topics:

Authors:

Ishihara

Kato Kato

Goto Goto

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.39.3236

A series of N-[ω-[N-alkyl-N-(phenylmethyl)amino]alkyl]-3-arylpropenamides was prepared and tested for its inhibitory activities on acetylcholinesterase. Some in the series were found to be potent inhibitors. The structure-activity relationships were discussed in detail.

Full text of DOI:10.1248/cpb.39.3236

NII-Electronic Library Service

Products guided by the article

Product name:2-Propenamide, N-acetyl-N-[4-[ethyl(phenylmethyl)amino]butyl]-3-(4-nitrophenyl)-, (E)-

Cas No:140134-47-0

R&D Labs maybe for 140134-47-0

Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.

Contact:+86-21-51320130-801, 816

Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Suzhou CarbonWell Pharma-Tech Co., Ltd

Contact:Tel: + 86 (0)512-8898-1216; + 86-18606258602

Address:2358 Changan Road, Wujiang Scientific Innovation Park, Wujiang, Jiangsu Province, P. R. China 215200
TIANJIN ZHONGXIN CHEMTECH CO.,LTD.

Contact:86-022-66880623

Address:FINANCIAL STREET WEST BLK 7, #308, NO.52 XINCHENG WEST ROAD, TEDA, TIANJIN, P.R.CHINA
Anqing World Chemical Co., Ltd.

Contact:+86-556-5800026

Address:Daguan Economic Development Zone of circular economy industrial park Anqing City Anhui province
Xi'an Costrong Pharmaceutical Co., Ltd.

Contact:029- 68576496

Address:Room 2004,Shuibao Building,No.190,South Erhuan Rd, Yanta District,Xi'an,Shaan Xi,China

Relevant to this article

Design of fullerene derivatives for stabilizing LUMO energy using donor groups placed in spatial proximity to the C₆₀ cage

Doi:10.1021/jo3015159
(2012)
Supermacrocyclic Assemblies by Hydrogen-Bond Codes of C7-Phenol Pyrazolo and Pyrrolo Derivatives of Adenine

Doi:10.1002/chem.201803429
(2018)
Synthesis of α-oxygenated ketones and substituted catechols via the rearrangement of N-enoxy- and N-aryloxyphthalimides

Doi:10.1016/j.tet.2017.01.061
(2017)
Human neutrophil elastase phosphonic inhibitors with improved potency of action

Doi:10.1021/jm300599x
(2012)
Total Synthesis and Biological Evaluation of Siladenoserinol A and its Analogues

Doi:10.1002/anie.201801659
(2018)
Semisynthetic Ursolic Acid Fluorolactone Derivatives Inhibit Growth with Induction of p21^waf1 and Induce Apoptosis with Upregulation of NOXA and Downregulation of c-FLIP in Cancer Cells

Doi:10.1002/cmdc.201200282
(2012)

Article Doi