Central cholinergic agents. II. Synthesis and acetylcholinesterase inhibitory activities of N-[ω-[N-alkyl-N-(phenylmethyl)amino]alkyl]-3-arylpropenamides

DOI: 10.1248/cpb.39.3236

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 3236 - 3243 (1991)

Update date:2022-08-04

Topics:

Authors:

Ishihara

Kato Kato

Goto Goto

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Article abstract of DOI:10.1248/cpb.39.3236

A series of N-[ω-[N-alkyl-N-(phenylmethyl)amino]alkyl]-3-arylpropenamides was prepared and tested for its inhibitory activities on acetylcholinesterase. Some in the series were found to be potent inhibitors. The structure-activity relationships were discussed in detail.

Full text of DOI:10.1248/cpb.39.3236

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Product name:2-Propenamide, N-acetyl-N-[4-[ethyl(phenylmethyl)amino]butyl]-3-(4-nitrophenyl)-, (E)-

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