Synthesis of Inhibitors of 2,3-Oxidosqualene-lanosterol Cyclase: Conjugate Addition of Organocuprates to N-(Carbobenzyloxy)-3-carbomethoxy-5,6-dihydro-4-pyridone

DOI: 10.1021/jo00036a008

Source and publish data:

Journal of Organic Chemistry p. 2794 - 2803 (1992)

Update date:2022-08-05

Topics:

Authors:

Dodd, Dharmpal S.

Oehlschlager, Allan C.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00036a008

Synthesis of ammonium ion analogues of the first cationic intermediate, 5, presumed to be formed during the cyclization of 2,3-oxidosqualene by 2,3-oxidosqualene-lanosterol cyclase are reported.The required 2,3-substituted-4-piperidinols are prepared by c

Full text of DOI:10.1021/jo00036a008

Products guided by the article

Product name:1-(carbobenzyloxy)-3-carbomethoxy-3-(phenylselenyl)-4-piperidone

Cas No:140176-28-9

R&D Labs maybe for 140176-28-9

Shanghai shibo Chemical Co., Ltd

Contact:+86-021-60753516

Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
Chinese Peptide Company

Contact:86-571-86737118-8689

Address:No.69, 12 Street, HEDA, Hangzhou, Zhejiang, China
Zouping Fuhai Technology Development Co., Ltd.

Contact:+0532-86934525 18660293207

Address:jiuhu town industrial park Zouping County,bingzhou Provincejiuhu town industrial park
Shanghai Hanshare Industry Co.,Ltd.

Contact:86 21 20960688

Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
Hangzhou Neway Chemicals Co., Ltd.

Contact:+86-571-85095566

Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China

Relevant to this article

Organocatalytic asymmetric anti-selective Michael reactions of aldehydes and the sequential reduction/lactonization/pauson-khand reaction for the enantioselective synthesis of highly functionalized hydropentalenes

Doi:10.1021/ol302527z
(2012)
A copper-mediated tandem reaction through isocyanide insertion into N-H bonds: Efficient access to unsymmetrical tetrasubstituted ureas

Doi:10.1039/c3cc47590e
(2014)
Reaction of o-carboranes with sterically demanding N-heterocyclic carbene: Synthesis and structural characterization of 1:1 adducts

Doi:10.1039/c2dt31765f
(2012)
Synthesis of benzo[c]phenanthridine alkaloids by Pd(OAc) ₂-induced direct aromatic carbonylation

Doi:10.1002/ejoc.201200262
(2012)
Photocatalysis by phenothiazine dyes: Visible-light-driven oxidative coupling of primary amines at ambient temperature

Doi:10.1021/ol302584y
(2012)
Arene Ruthenium(II) Complexes as Low-Toxicity Inhibitor against the Proliferation, Migration, and Invasion of MDA-MB-231 Cells through Binding and Stabilizing c-myc G-Quadruplex DNA

Doi:10.1021/acs.organomet.5b00820
(2016)

Article Doi