Asymmetric Synthesis of Oxygen- and Nitrogen-Substituted Difluoromethylene Products

Article abstract of DOI:10.1021/jo00035a035

1,1-Difluoroalkyl sulfinylmethyl ketones 3 are synthesized in enantiomerically pure form through acylation of (+)-(R)-methyl p-tolyl sulfoxide (1) with α,α-difluorocarboxylates 2.These ketones have been reduced with complete diastereoselection to give the