Stereoselective Synthesis of Trifluoromethylated Compounds with Controlled Adjacent Tertiary Carbons by Michael Addition to (E)-3-(Trifluoromethyl)acrylates

DOI: 10.1021/jo00119a013

Source and publish data:

Journal of Organic Chemistry p. 4363 - 4374 (1995)

Update date:2022-08-03

Topics:

Authors:

Shinohara, Noriyasu

Haga, Jiro

Yamazaki, Takashi

Kitazume, Tomoya

Nakamura, Shinichiro

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00119a013

Michael addition reaction of various lithium enolates to ethyl (E)-3-(trifluoromethyl)acrylate (E)-1 was found to be one of the most effective routes to construct materials not only with a CF3 group but also readily distinguishable multiple functionalitie

Full text of DOI:10.1021/jo00119a013

Products guided by the article

Product name:(3R*,4R*)-Ethyl 3-(trifluoromethyl)-4-methyl-5-oxo-5-phenylpentanoate

Cas No:138921-71-8

R&D Labs maybe for 138921-71-8

hangzhou verychem science and technology co.ltd

website:http://www.verypharm.com

Contact:+86-571-88162785; 88162786

Address:F1502, 753 Shenhua road, Hangzhou, China
Ningbo Inno Pharmchem Co., Ltd.

Contact:86-574-87319282

Address:6F-5,NO.163 RUIQING RD.,NINGBO 315000 CHINA
HANGZHOU YUNUO CHEMICAL CO.,LTD

website:http://www.yunuochem.com

Contact:0571-83715115

Address:hangzhou
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou
Anhui Gusheng Import&Export CO.,LTD

Contact:86-551-63662296

Address:Jinzhai Road NO.162 ,hefei, china

Relevant to this article

Arylgold(I) complexes from base-assisted transmetalation: Structures, NMR properties, and density-functional theory calculations

Doi:10.1021/ic3009464
(2012)
Trifluoromethylation of aromatic compounds with sodium trifluoromethanesulfinate under oxidative conditions

Doi:10.1016/0040-4039(91)80524-A
(1991)
Efficient macrocyclization by a novel oxy-oxonia-cope reaction: Synthesis and olfactory properties of new macrocyclic musks

Doi:10.1002/chem.201200882
(2012)
Synthesis, in vitro screening and docking studies of new thiosemicarbazide derivatives as antitubercular agents

Doi:10.3390/molecules24020251
(2019)
Wacker oxidation methodology for the synthesis of the benzo-fused acetal core of marticin

Doi:10.1016/j.tet.2012.06.052
(2012)
Catalytic Enantioselective Conversion of Epoxides to Thiiranes

Doi:10.1021/jacs.6b01960
(2016)

Article Doi