Dynamic kinetic resolution of 2,3-dihydrobenzo[be]furans: Chemoenzymatic synthesis of analgesic agent BRL 37959

DOI: 10.1002/chem.201200683

Source and publish data:

Chemistry - A European Journal p. 11063 - 11070 (2012)

Update date:2022-07-29

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Authors:

Bongen, Patrick

Pietruszka, J?rg

Simon, Robert Christian

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Article abstract of DOI:10.1002/chem.201200683

An efficient asymmetric synthesis of (S)-2,3-dihydrobenzo[be]furan-3- carboxylic acid (8 ) and (S)-5-chloro-2,3-dihydrobenzo[be]furan-3-carboxylic acid (8a b) was established. Key to the success was the highly stereoselective enzymatic kinetic resolution

Full text of DOI:10.1002/chem.201200683

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